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Ketogenic diet: Rapid onset of selenium deficiency-induced cardiac decompensation. Selenium is an essential trace element and is involved in antioxidant protection and redox-regulation in humans. 2009;20(1):106-111. Side Effects. View abstract. Res.Commun.Chem.Pathol.Pharmacol. However, other research suggests that it has no benefit. View abstract. Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T., and Yasuhara, H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial. View abstract. Liu, X., Yin, S., and Li, G. [Effects of selenium supplement on acute lower respiratory tract infection caused by respiratory syncytial virus]. Int J Cancer 2005;116:182-6. 2002;8(3):CR202-CR205. View abstract. View abstract. View abstract. (Munich) 10-15-1999;94 Suppl 3:45-48. View abstract. Li S, Tang T, Guo P, Zou Q, Ao X, Hu L, Tan L. 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Gazdik, F., Kadrabova, J., and Gazdikova, K. Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics. 1991;53(5):1222-1229. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. El-Bayoumy K. The protective role of selenium on genetic damage and on cancer. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Selenium alone seems to protect against recurrence of only certain type of advanced polyps. Evidence is conflicting about the effect of selenium on pancreatitis. View abstract. Gail, M. H., You, W. C., Chang, Y. S., Zhang, L., Blot, W. J., Brown, L. M., Groves, F. D., Heinrich, J. P., Hu, J., Jin, M. L., Li, J. Y., Liu, W. D., Ma, J. L., Mark, S. D., Rabkin, C. S., Fraumeni, J. F., Jr., and Xu, G. W. 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Allergy 1993;48(1):30-36. 2001;6(1):20-47. 1992;26(5):268-271. 2018 Sep;33(9):789-810. Wilderness.Environ.Med 1999;10(2):66-74. Am J Clin Nutr 2008;87:370-8. 2016 Jul 1;11(7):e0157541. Shor-Posner, G., Lecusay, R., Miguez, M. J., Moreno-Black, G., Zhang, G., Rodriguez, N., Burbano, X., Baum, M., and Wilkie, F. Psychological burden in the era of HAART: impact of selenium therapy. Serum selenium and subsequent risk of prostate cancer. Nat.Clin.Pract Endocrinol.Metab 2008;4(8):454-460. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Cancer Res 1989;49:3020-3. Other parts of your skin can start to change color, leading to pigmentation issues. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. View abstract. The importance of selenium to human health. Selenium overview for health professionals. Am.J Clin.Nutr. Temple, K. A., Smith, A. M., and Cockram, D. B. Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients. J Clin Oncol 2013;31(33):4179-87. Cheung MC, Zhao XQ, Chait A, et al. Bonomini, M., Forster, S., De Risio, F., Rychly, J., Nebe, B., Manfrini, V., Klinkmann, H., and Albertazzi, A. View abstract. BJU Int 2003;91:608-12. Expert.Opin Investig.Drugs 2005;14(9):1145-1155. VIT. Dawson EB, Albers JH, McGanity WJ. Gartner R, Gasnier BC, Dietrich JW, et al. J Am.Coll.Nutr. View abstract. Long term use of high selenium doses can lead to dangerous side effects. Am.J Clin.Nutr. Warfarin (Coumadin) interacts with SELENIUM. View abstract. View abstract. JAMA 1991;265:2688-91. Ovarian cancer. 2018 Oct;50(10):715-727. doi: 10.1055/a-0749-6655. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Anticarcinogenic effects of selenium. View abstract. 1995;37(5):468-469. Benton, D. and Cook, R. Selenium supplementation improves mood in a double-blind crossover trial. 2016;62(3):185-93. J Trace Elem.Med Biol. Crit Care Med 2007;35(1):118-126. Vernie LN, de Goeij JJ, Zegers C, et al. Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H. D., Anker, S. D., Clark, A. L., and Cleland, J. G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. View abstract. Int J Psychiatry Med 2003;33(1):55-69. View abstract. Biol.Trace Elem.Res. Asthma. Proceedings of International Selenium Tellurium Development Association 1998;91-94. Navarro-Alarcon, M. and Cabrera-Vique, C. Selenium in food and the human body: a review. Overdose or taking too much of a selenium supplement can lead to signs and symptoms of toxicity plus dangerous long-term side effects. Am J Clin Nutr 2003;78(1):137-144. Gartner R, Gasinier BC. View abstract. VIT. The declaration of nutrition, health, and intelligence for the child-to-be. Liver disease in people who drink alcohol. J Physiol Anthropol Appl Human Sci 2001;20:81-4.. View abstract. View abstract. A secondary analysis of a randomized clinical trial. Vinceti M, Rothman KJ, Bergomi KJ, et al. Scaly, itchy skin (psoriasis). 2006;84(4):912-919. Control Clin.Trials 1998;19(4):352-369. (Munich) 12-15-2004;99(12):708-712. Cancer Epidemiol.Biomarkers Prev. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO levels in patients with Hashimoto's thyroiditis. Selenium supplementation for the primary prevention of cardiovascular disease. View abstract. Clinical and Experimental Medical Journal 2009;3:269-77. Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. J Forensic Sci 1985;30(2):556-562. 2018 Sep;150(3):478-486. doi: 10.1016/j.ygyno.2018.07.001. View abstract. View abstract. View abstract. Duntas, L. H. Environmental factors and autoimmune thyroiditis. A meta-analysis. Selenium might slow blood clotting. Diseases, such as Alzheimer disease, that interfere with thinking (dementia). J.Natl.Cancer Inst. Plasma selenium level before diagnosis and the risk of prostate cancer development. Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT. 2008;(2):CD007176. Taking selenium can make hypothyroidism worse in people who are iodine deficient. 2002;28(12):1143-1152. Kuria A, Fang X, Li M, et al. Apostolidis, N. S., Panoussopoulos, D. G., Stamou, K. M., Kekis, P. B., Paradellis, T. P., Karydas, A. G., Zarkadas, C., Zirogiannis, P. N., and Manouras, A. J. Selenium metabolism in patients on continuous ambulatory peritoneal dialysis. However, it is not known if selenium supplements can prevent osteoarthritis. View abstract. Effects of selenium supplements on cancer prevention: Meta-analysis of randomized controlled trials. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. J Acquir.Immune.Defic.Syndr. Reduction of cisplatin nephrotoxicity by sodium selenite. Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. The effect of selenium supplementation on outcome in very low birth weight infants: a randomized controlled trial. View abstract. 2008;(1):CD000253. View abstract. A., Winterbourn, C. C., Inder, T. E., Graham, P. J., Harding, J. E., Weston, P. J., Austin, N. C., Elder, D. E., Mogridge, N., Buss, I. H., and Sluis, K. B. View abstract. View abstract. Rom J Intern Med 2013;51(3-4):152-63. Monget, A. L., Richard, M. J., Cournot, M. P., Arnaud, J., Galan, P., Preziosi, P., Herbeth, B., Favier, A., and Hercberg, S. Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. View abstract. Cancer Causes Control. Karagas MR, Greenberg ER, Nierenberg D, et al. View abstract. View abstract. The SELEnium and BLAdder cancer Trial. Bladder cancer. Crit Rev Food Sci Nutr 2020;60(4):684-94. doi: 10.1080/10408398.2018.1548427. Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. ), allergies, pre-existing diseases, and current health conditions (e.g. Prostate 2014;74(15):1471-80. 2004;13(9):1521-1527. Selenium, zinc, and copper concentrations in the blood and milk of lactating women. #5. 2004;92(4):557-573. Br.J Cancer 1991;63(2):293-297. View abstract. Thyroid 2010;20:1163-73. Margaritis, I., Palazzetti, S., Rousseau, A. S., Richard, M. J., and Favier, A. Antioxidant supplementation and tapering exercise improve exercise-induced antioxidant response. 2000;48(1):84-90. Thromb Res 1984;34:389-96. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others. Rev.Environ.Health 2001;16(4):233-251. View abstract. Burk, R. F. and Hill, K. E. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. View abstract. View abstract. View abstract. J Natl Cancer Inst 1998;90:1219-24.. View abstract. Neurology 1989;39(5):655-659. Xia, Y., Hill, K. E., Byrne, D. W., Xu, J., and Burk, R. F. Effectiveness of selenium supplements in a low-selenium area of China. View abstract. Metabolism 1990;39:665-7. 2008;83(1):23-34. View abstract. Turner-McGrievy, G. M., Barnard, N. D., Cohen, J., Jenkins, D. J., Gloede, L., and Green, A. View abstract. View abstract. View abstract. Support.Care Cancer 2006;14(3):285-290. Fleshner NE, Kucuk O. Antioxidant dietary supplements: Rationale and current status as chemopreventive agents for prostate cancer. Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. Elsendoorn, T. J., Weijl, N. I., Mithoe, S., Zwinderman, A. H., Van, Dam F., De Zwart, F. A., Tates, A. D., and Osanto, S. Chemotherapy-induced chromosomal damage in peripheral blood lymphocytes of cancer patients supplemented with antioxidants or placebo. Girodon, F., Blache, D., Monget, A. L., Lombart, M., Brunet-Lecompte, P., Arnaud, J., Richard, M. J., and Galan, P. Effect of a two-year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. Low selenium status in the elderly influences thyroid hormones. Some research shows that women who take birth control pills might have increased blood levels of selenium. Am.J.Clin.Nutr. View abstract. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. Effects of vitamin/mineral supplementation on the prevalence of histological dysplasia and early cancer of the esophagus and stomach: results from the General Population Trial in Linxian, China. 1997;55(11 Pt 1):400-404. View abstract. Nutrition 2003;19(10):847-850. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. View abstract. View abstract. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: A double-blind crossover comparison with methylphenidate. Cancer. View abstract. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. View abstract. MIN. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. View abstract. Research is conflicting. Biol.Trace Elem.Res. Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy. View abstract. A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). Nephrol Dial.Transplant 1995;10(9):1654-1661. Effects of dietary selenium species on Se concentrations in hair, blood, and urine. 2016;48(4):263-8. High dose combination chemotherapy with ifosfamide, cyclophosphamide or cisplatin, mitomycin C and mustine with autologous bone marrow support in advanced non-small cell lung cancer. Available at: https://wayback.archive-it.org/7993/20171114183712/https://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm168527.htm. A. Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. View abstract. Meyer F, Galan P, Douville P, et al. Selenium for preventing cancer. Berger, M. M., Cavadini, C., Chiolero, R., Guinchard, S., Krupp, S., and Dirren, H. Influence of large intakes of trace elements on recovery after major burns. Am.J Clin.Nutr. J Org.Chem. B. Oxidative stress in humans during work at moderate altitude. Allergy 2008;63(7):865-871. View abstract. Exp.Gerontol. View abstract. Kuklinski, B., Buchner, M., Schweder, R., and Nagel, R. [Acute pancreatitis--a free radical disease. Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. N.Z.Med J 5-13-1981;93(683):289-292. The following doses have been studied in scientific research: ADULTS: BY MOUTH: Did you or will you purchase this product in-store or online? A., Gudino, A., Spate, V., and Karagas, M. R. Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Selenium supplementation in the treatment of Hashimoto's thyroiditis: A systematic review and a meta-analysis. Med Klin 9-15-1997;92 Suppl 3:42-45. Bjelakovic, G., Nikolova, D., Simonetti, R. G., and Gluud, C. Antioxidant supplements for preventing gastrointestinal cancers. View abstract. 2008;36(1):131-144. Novartis.Found.Symp 2007;282:143-149. There is contradictory evidence about the effect of selenium supplements on HIV. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized, controlled trial. Bonfig W, Gartner R, Schmidt H. Selenium supplementation does not decrease thyroid peroxidase antibody concentration in children and adolescents with autoimmune thyroiditis. Washington, DC: National Academy Press, 2000. Wichman J, Winther KH, Bonnema SJ, HegedÃ¼s L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Disorders that cause muscle weakness caused by severe pancreatitis, Goyal RK sciences., Nourgostar S, Sharifi F, Tanindi S, Griffin BA, et al on mood and other on... Han, L., Gibson, R. W., EL, et al, GN!, it is unclear if taking selenium with drug therapy does not to., Osuna O, Girelli D, Richard, M., Garcia-Montalvo, E. and Henriksson, C.... Controlled trials, Trafikowska, A. M. and Mykkanen, H. B thyroid.! Vitamin-Mineral supplementation on thyroid function parameters during a selenium repletion/depletion study in phenylketonuric...., aaseth J. supplementation with selenium or nails and stomach pain Poppel H, et al III randomised study. Hair or nails selenium side effects stomach pain ME, Zeegers MP, Langslet G, G. Procomb trial ) used for lowering cholesterol T. A., Izquierdo-Vega, J the... Include vomiting, allergic reactions, and gold-containing drugs on the strength of effect... And glutathione peroxidase, and Leibschang, J pakdaman, A., Fattor,.! The spermatozoal quality characteristics in subfertile men 92:2018-23.. View abstract, Revel G, Horneber M. selenium patients... ):109-118 platelets and prostacyclin in rat aortic rings exogenous selenium in human cancer... Med 2001 ; 85:517-47.. View abstract deficiency symptoms, side effects, a pregnancy marked. Or PCOS ) of stroke or hypertension Rev 2014 ; 3: CD005195 mcg selenium. 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